Traumatic brain Injury (TBI) is a major public healthcare concern, affecting people of all ages. Despite advances in the diagnosis, monitoring and clinical management of TBI, many unresolved questions remain regarding its physiopathology. ⋯ In turn, each model represents a specific type of trauma and evaluates a specific physiopathological aspect of the cascade triggered as a result of TBI. This review describes the main experimental models currently available referred to TBI and their possible application to the clinical setting.
Med Intensiva. 2019 Aug 1; 43 (6): 362-372.
Abstract Traumatic brain Injury (TBI) is a major public healthcare concern, affecting people of all ages. Despite advances in the diagnosis, monitoring and clinical management of TBI, many unresolved questions remain regarding its physiopathology. In an attempt to understand the pathological features of TBI and to evaluate single potential therapeutic strategies, various animal models have been developed to simulate the mechanisms of action and the clinical manifestations of TBI patients. In turn, each model represents a specific type of trauma and evaluates a specific physiopathological aspect of the cascade triggered as a result of TBI. This review describes the main experimental models currently available referred to TBI and their possible application to the clinical setting.Copyright © 2018 Elsevier España, S.L.U. y SEMICYUC. All rights reserved.
You can also include formatting, links, images and footnotes in your notes
Simple formatting can be added to notes, such as *italics*, _underline_ or **bold**.
Superscript can be denoted by <sup>text</sup> and subscript <sub>text</sub>.
Numbered or bulleted lists can be created using either numbered lines 1. 2. 3., hyphens - or asterisks *.
Links can be included with: [my link to pubmed](http://pubmed.com)
Images can be included with: 
For footnotes use [^1](This is a footnote.) inline.
Or use an inline reference [^1] to refer to a longer footnote elseweher in the document [^1]: This is a long footnote..