• J. Cardiothorac. Vasc. Anesth. · Apr 2019

    Preoperative QTc Interval is Not Associated With Intraoperative Cardiac Events or Mortality in Liver Transplantation Patients.

    • Devon Flaherty, Sang Kim, Jeron Zerillo, Chang Park, Thomas Joseph, Bryan Hill, Hung-Mo Lin, Jiawen Li, Carlyle Hamsher, Menachem M Weiner, and Samuel DeMaria.
    • Department of Anesthesiology, Perioperative, and Pain Medicine, Icahn School of Medicine at Mount Sinai, New York, NY.
    • J. Cardiothorac. Vasc. Anesth. 2019 Apr 1; 33 (4): 961-966.

    ObjectivesThe primary objective of this study was to determine whether liver transplantation recipients with preoperative prolonged corrected (QTc) intervals have a higher incidence of intraoperative cardiac events and/or postoperative mortality compared with their peers with normal QTc intervals.DesignThis was a retrospective cohort study.SettingSingle academic hospital in New York, NY.ParticipantsPatients undergoing liver transplantation between 2007 and 2016.InterventionsNone.Measurements And Main ResultsData relating to all liver transplantation recipients with preoperative electrocardiograms were queried from an institutional anesthesia data warehouse and electronic medical records. Primary outcomes were a composite outcome of intraoperative cardiac events and postoperative mortality. Patients with a prolonged QTc interval (>450 ms for men, >470 ms for women) did not demonstrate an association with intraoperative cardiac events, 30- or 90-day mortality, in-hospital mortality, or overall mortality compared with recipients in the normal QTc interval group. A prolonged QTc was found to be associated with increased anesthesia time, surgical time, length of hospital stay, and incidence of fresh frozen plasma and platelets transfusion.ConclusionsProlonged QTc interval is not associated with an increased incidence of intraoperative cardiac events or mortality in liver transplantation recipients. The demonstrated correlation among QTc length and Model for End-stage Liver Disease score, blood component requirements, surgical and anesthetic times, and hospital length of stay likely represents the association between QTc length and severity of liver disease.Copyright © 2018 Elsevier Inc. All rights reserved.

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