• Sonderen Agnes van AV Department of Neurology, Erasmus Medical Center, Rotterdam, The Netherlands. Depar, Samuel Arends, Tavy Dénes L J DLJ Department of Neurology, Haga Teaching Hospital, The Hague, The Netherlands., Anna E M Bastiaansen, Marienke A A M de Bruijn, Schreurs Marco W J MWJ Department of Immunology, Erasmus Medical Center, Rotterdam, The Netherlands., Sillevis Smitt Peter A E PAE Department of Neurology, Erasmus Medical Center, Rotterdam, The Netherlands., and Maarten J Titulaer.
• Department of Neurology, Erasmus Medical Center, Rotterdam, The Netherlands.
• J. Neurol. Neurosurg. Psychiatr. 2018 Oct 1; 89 (10): 1101-1106.

ObjectivesAnti-N-methyl-D-aspartate receptor encephalitis (anti-NMDARE) is a severe, but treatable disease. This study aims to give a detailed description of electroencephalogram (EEG) results in paediatric and adult patients to improve disease recognition, and analyses the predictive value of the first EEG for the final clinical outcome.MethodsThis nationwide cohort study includes patients with N-methyl-D-aspartate receptor antibodies confirmed with cell-based assay and immunohistochemistry in serum and cerebrospinal fluid. EEG recordings were re-evaluated by two experienced neurophysiologists, mixed with control EEGs for blinding. Initial EEG as well as follow-up registrations were analysed.Results35 adults and 18 children were included. Only two patients (4%) had a normal EEG. During the first recording, the majority of the patients had normal posterior rhythm (71%), which was associated with better modified Rankin Scale at final outcome (OR 4.74; 95% CI 1.56 to 14.47; p=0.006). In addition, EEGs showed focal (73%) or diffuse (67%) slowing. The first EEG was severely abnormal in 26%. However, 8 of 14 patients with a severely abnormal first EEG still had a favourable outcome. During the course of the disease, extreme delta brushes (EDBs) were present in 6 of 53(11%)patients.ConclusionsThe first EEG commonly shows normal posterior rhythm with focal or diffuse slowing. Although the sensitivity of an abnormal EEG is high (96%), normal EEG does not exclude anti-NMDARE. EDBs are only present in severely affected patients. The first EEG recording is predictive of the final clinical outcome.© Author(s) (or their employer(s)) 2018. No commercial re-use. See rights and permissions. Published by BMJ.

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