• Obaid S Malik, Ethan Y Brovman, and Richard D Urman.
• Department of Anesthesia, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA.
• J. Cardiothorac. Vasc. Anesth. 2019 Apr 1; 33 (4): 935-942.

ObjectiveOver 150,000 carotid endarterectomy (CEA) procedures are performed each year. Perioperative anesthetic management may be complex due to multiple patient and procedure-related risk factors. The authorsaimed to determine whether the use of general anesthesia (GA), when compared with regional anesthesia (RA), would be associated with reduced perioperative morbidity and mortality in patients undergoing a CEA.DesignRetrospective analysis of the American College of Surgeons National Surgical Quality Improvement Program (NSQIP) database.SettingThe authors evaluated patients undergoing a CEA at multiple university- and community-based settings.ParticipantsA total of 43,463 patients were identified; 22,845 patients were propensity matched after excluding for missing data.InterventionsThe study population was divided into 2 groups: patients undergoing RA or GA. The RA group included regional anesthesia performed by the anesthesiologist or surgeon, monitored anesthesia care, and local infiltration.MethodsThe primary endpoint was 30-day mortality. Secondary endpoints included surgical site infection, pulmonary complications, return to the operating room, acute kidney injury, cardiac arrest, urinary tract infection, myocardial infarction, thromboembolism, perioperative transfusion, sepsis, and days to discharge.Measurements And Main ResultsYounger age, Hispanic ethnicity, body mass index <18.5, dyspnea, chronic obstructive pulmonary disease, and smoking history were associated with receiving GA. Patients with low hematocrit and low platelets were more likely to get RA. There was no mortality difference. GA was associated with a significantly higher rate of perioperative transfusions (p = 0.037) and perioperative pneumonia (p = 0.027).ConclusionThe use of RA over GA in CEA is associated with decreased risk of postoperative pneumonia and a reduced need for perioperative blood transfusions.Copyright © 2018 Elsevier Inc. All rights reserved.

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