• Anesthesia and analgesia · Jul 2019

    Comparative Study

    Predosing Chemical Stability of Admixtures of Propofol, Ketamine, Fentanyl, and Remifentanil.

    • Peter Bedocs, David L Evers, and Chester C Buckenmaier.
    • From the Defense and Veterans Center for Integrative Pain Management, Henry M. Jackson Foundation, Rockville, Maryland.
    • Anesth. Analg. 2019 Jul 1; 129 (1): e13-e15.

    AbstractAdmixtures of propofol-ketamine, propofol-ketamine-fentanyl, and propofol-ketamine-remifentanil were subjected to various clinically relevant conditions to study their chemical stability. A novel high-performance liquid chromatography-mass spectrometry method revealed no degradation of any compound by incubation at 37°C, constant mixing, or table-top storage for 6- and 24-hour time periods, except variable recovery of both propofol and fentanyl in the admixtures of propofol-ketamine-fentanyl suggesting possible degradation.

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