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- Jaime P Almandoz and Hossein Gharib.
- Mayo School of Graduate Medical Education, College of Medicine, Mayo Clinic, Rochester, MN 55905, USA.
- Med. Clin. North Am. 2012 Mar 1; 96 (2): 203-21.
AbstractHypothyroidism is the result of inadequate production of thyroid hormone or inadequate action of thyroid hormone in target tissues. Primary hypothyroidism is the principal manifestation of hypothyroidism, but other causes include central deficiency of thyrotropin-releasing hormone or thyroid-stimulating hormone (TSH), or consumptive hypothyroidism from excessive inactivation of thyroid hormone. Subclinical hypothyroidism is present when there is elevated TSH but a normal free thyroxine level. Treatment involves oral administration of exogenous synthetic thyroid hormone. This review presents an update on the etiology and types of hypothyroidism, including subclinical disease; drugs and thyroid function; and diagnosis and treatment of hypothyroidism.Copyright © 2012 Elsevier Inc. All rights reserved.
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