• An Pediatr (Barc) · Dec 2013

    Case Reports

    [Hemiparesis and facial palsy caused by methotrexate].

    • E Rueda Arenas, J García Corzo, and L Franco Ospina.
    • Servicio de Oncología Pediátrica, Departamento de Pediatría, Universidad Industrial de Santander, Servicio de Oncología Pediátrica Hospital Universitario de Santander, Bucaramanga, Colombia.
    • An Pediatr (Barc). 2013 Dec 1; 79 (6): 385-9.

    AbstractMethotrexate used in the treatment of acute lymphocytic leukemia, can cause neurotoxicity, including a rare presentation with hemiparesis. We describe two teenagers, who during the implementation of the M phase of the protocol, suffered hemiparesis, facial paresis and dysarthria which quickly reversed. Leukemia involvement of the central nervous system and stroke, were ruled out. We briefly review the pathophysiology of methotrexate neurotoxicity, the characteristics of the focal paresis presentation and magnetic resonance image findings. Copyright © 2013 Asociación Española de Pediatría. Published by Elsevier Espana. All rights reserved.

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