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Comparative Study
Continuous renal replacement therapy: does technique influence electrolyte and bicarbonate control?
- H Morimatsu, S Uchino, R Bellomo, and C Ronco.
- Department of Intensive Care and Department of Medicine, Austin & Repatriation Medical Centre, Melbourne, Victoria, Australia.
- Int J Artif Organs. 2003 Apr 1; 26 (4): 289-96.
Background And ObjectivesDifferent techniques of continuous renal replacement therapy (CRRT) might have different effects on electrolyte and acid-base control. The aim of this study was to determine whether continuous veno-venous hemodiafiltration (CVVHDF) or continuous veno-venous hemofiltration (CVVH) achieve better control of serum sodium, potassium and bicarbonate concentrations.DesignRetrospective controlled study.SettingTwo tertiary intensive care units.PatientsCritically ill patients with acute renal failure (ARF) treated with CVVHDF (n=49) or CVVH (n=50).InterventionsRetrieval of daily morning sodium and potassium values and arterial bicarbonate levels from computerized biochemical records before and after the initiation of CRRT for up to 2 weeks of treatment. Statistical comparison of findings.Measurements And ResultsBefore treatment, abnormal (high or low) values were frequently observed for sodium (65.1% for CVVHDF vs. 80.0% for CVVH; NS), potassium (45.9% vs. 34.0%; NS), and bicarbonate (73.3% vs. 68.0%; NS). After treatment, however, CVVHDF was more likely to achieve serum sodium concentrations within the normal range (74.1% vs. 62.9%; p=0.0026). Both treatments decreased the mean serum potassium concentration over the first 48 h (p=0.0059 and p<0.0001, respectively), but there was no difference in terms of the normalization of serum potassium concentration during the entire treatment period (88.3% vs. 90.5%; NS). Both treatments increased the mean arterial bicarbonate concentration over the first 48 hours (p=0.011 and p<0.0001, respectively). However, CVVH was associated with a lower incidence of metabolic acidosis (13.8% for CVVH vs. 34.5% for CVVHDF; p<0.0001) and a higher incidence of metabolic alkalosis (38.9% vs. 1.1%; p<0.0001) during the entire treatment period.ConclusionsCRRT strategies based on different techniques have a significantly different impact on sodium and bicarbonate control.
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