• JAMA · Mar 2013

    Review

    Antiplatelet therapy to prevent cardiovascular events and mortality in patients with intermittent claudication.

    • Peng Foo Wong, Lee-Yee Chong, and Gerard Stansby.
    • Department of Vascular Surgery, James Cook University Hospital, Marton Road, Middlesbrough, Cleveland, TS4 3BW England. pwong23@hotmail.com
    • JAMA. 2013 Mar 6;309(9):926-7.

    Clinical QuestionDo antiplatelet therapies reduce risk of all-cause mortality, cardiovascular disease (CVD) mortality, and cardiovascular events in patients with intermittent claudication? Which antiplatelet is most strongly associated with a reduced risk of all-cause and CVD mortality?Bottom LineIn patients with intermittent claudication, antiplatelet therapies are associated with lower all-cause and CVD mortality compared with placebo. Compared with all antiplatelet therapies, the strongest evidence exists for thienopyridines, such as clopidogrel.

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