• Pain Med · Oct 2018

    Randomized Controlled Trial Comparative Study

    A Comparison of Prilocaine vs Prilocaine + Bupivacaine in Periprostatic Block in Ambulatory Prostate Biopsies: A Single-Blind Randomized Controlled Study.

    • Ekrem Akdeniz, Mustafa Suat Bolat, and Sevda Akdeniz.
    • Department of Urology.
    • Pain Med. 2018 Oct 1; 19 (10): 2069-2076.

    ObjectiveThe purpose of this study was to evaluate the analgesic effect of a prilocaine + bupivacaine combination in patients undergoing periprostatic nerve block (PNB) by comparing its effects with those of prilocaine alone.DesignSingle center, single-blind, prospective descriptive study.SubjectsFour hundred patients with transrectal prostate biopsy pain.MethodsThe patients in this prospective, randomized controlled study were divided into two groups. The first group received prilocaine during PNB (Group 1), whereas the second received a prilocaine + bupivacaine combination (Group 2).ResultsThe mean visual analog scale (VAS) scores immediately after biopsy were 2.52 ± 0.7 and 2.53 ± 0.9, respectively (P = 0.35). VAS values were significantly lower in Group 2 at one and six hours following the procedure. The most painful part of the biopsy according to many patients was the probe insertion.ConclusionsThe prilocaine + bupivacaine combination is an effective analgesic method during prostate biopsies and for one and six hours after prostate biopsy.

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