• JAMA · Oct 2018

    Meta Analysis

    Bisphosphonates for Patients Diagnosed With Multiple Myeloma.

    • Rahul Mhaskar and Benjamin Djulbegovic.
    • Morsani College of Medicine, Division of Evidence Based Medicine, Department of Internal Medicine, University of South Florida, Tampa.
    • JAMA. 2018 Oct 9; 320 (14): 1483-1484.

    Clinical QuestionAmong patients with multiple myeloma, is bisphosphonate therapy associated with lower rates of mortality, vertebral fractures, nonvertebral fractures, and skeletal-related events compared with placebo or no treatment?Bottom LineAmong patients with myeloma, bisphosphonates were associated with lower rates of pathological fractures and skeletal-related events compared with placebo or no treatment. Direct meta-analysis showed no association between bisphosphonates and mortality. In network meta-analysis, zoledronate was associated with lower risk of mortality compared with placebo or no treatment.

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