Reperfusion Changes After Stroke and Practical Approaches for

Neuroimaging Clin. N. Am. · Nov 2018

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Reperfusion Changes After Stroke and Practical Approaches for Neuroprotection.

Reperfusion is the first line of care in a growing number of eligible acute ischemic stroke patients. Early reperfusion with thrombolytic drugs and endovascular mechanical devices is associated with improved outcome and lower mortality rates compared with natural history. ⋯ In this article, the functional and structural changes and underlying molecular mechanisms of ischemia and reperfusion are reviewed. The pathways that lead to reperfusion injury and novel neuroprotective strategies with endogenous properties are discussed.

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- Jae H Choi and John Pile-Spellman.
- Center for Unruptured Brain Aneurysms, Neurological Surgery PC, 1991 Marcus Avenue, Suite 108, Lake Success, NY 11042, USA; Department of Neurology, State University of New York Downstate Medical Center, 450 Clarkson Avenue, Brooklyn, NY 11203, USA; Hybernia Medical LLC, 626 RexCorp Plaza, Uniondale, NY 11556, USA. Electronic address: jae.h.choi.0524@gmail.com.
- Neuroimaging Clin. N. Am. 2018 Nov 1; 28 (4): 663-682.
AbstractReperfusion is the first line of care in a growing number of eligible acute ischemic stroke patients. Early reperfusion with thrombolytic drugs and endovascular mechanical devices is associated with improved outcome and lower mortality rates compared with natural history. Reperfusion is not without risk, however, and may result in reperfusion injury, which manifests in hemorrhagic transformation, brain edema, infarct progression, and neurologic worsening. In this article, the functional and structural changes and underlying molecular mechanisms of ischemia and reperfusion are reviewed. The pathways that lead to reperfusion injury and novel neuroprotective strategies with endogenous properties are discussed.Copyright © 2018 Elsevier Inc. All rights reserved.

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Reperfusion Changes After Stroke and Practical Approaches for Neuroprotection.

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