• World Neurosurg · Sep 2018

    Perioperative and Postoperative Quality of Life in Patients with Glioma-A Longitudinal Cohort Study.

    • Christina Drewes, Lisa Millgård Sagberg, Asgeir Store Jakola, and Ole Solheim.
    • Department of Neuromedicine and Movement Science, Norwegian University of Science and Technology, Trondheim, Norway; Department of Anesthesiology, St. Olavs University Hospital, Trondheim, Norway. Electronic address: christina.drewes@ntnu.no.
    • World Neurosurg. 2018 Sep 1; 117: e465-e474.

    ObjectiveFew studies have assessed patient-reported quality of life (QoL) in patients with glioma undergoing surgery, and even fewer have provided longitudinal data. Accordingly, there is little knowledge about the changes of QoL over time in patients with glioma. We sought to explore perioperative and postoperative development of generic QoL during the first 6 months after primary glioma surgery.MethodsA total of 136 adult patients undergoing primary surgery for high-grade glioma (HGG) or low-grade glioma (LGG) were prospectively included in this explorative longitudinal study. Patient-reported QoL was measured with the generic tool EQ-5D 3L preoperatively and at 1 and 6 months after surgery.ResultsAt group level, there was no difference in EQ-5D index values in patients with HGG compared with patients with LGG at baseline or at 1 month. At 6 months, EQ-5D index values in patients with HGG had deteriorated significantly (P < 0.001) but remained stable in patients with LGG. Individual level QoL development was more diverse. American Society of Anesthesiologists class ≥3, resection grades other than gross total resection, and HGG were identified as independent predictors for negative development of QoL between 1 and 6 months after surgery.ConclusionsAt group level, development of generic QoL between baseline and 1 and 6 months postoperatively seems to follow the natural disease trajectories of LGG and HGG, with deterioration in patients with HGG at 6 months. Individual development of QoL is heterogeneous. HGG, resection grades other than gross total resection, and preoperative comorbidity are predictors of postoperative impairment of QoL.Copyright © 2018 The Author(s). Published by Elsevier Inc. All rights reserved.

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