• A&A practice · Aug 2018

    Case Reports

    Vitamin C for Vasoplegia After Cardiopulmonary Bypass: A Case Series.

    • Patrick M Wieruszewski, Scott D Nei, Simon Maltais, Hartzell V Schaff, and Erica D Wittwer.
    • From the Departments of Pharmacy.
    • A A Pract. 2018 Aug 15; 11 (4): 96-99.

    AbstractCardiac vasoplegia remains a significant contributor of morbidity and mortality in cardiac surgery patients after cardiopulmonary bypass. Effective therapeutic options for vasopressor-refractory vasoplegia are limited. We report 3 patients in whom we administered high-dose intravenous ascorbic acid (vitamin C), a cofactor for endogenous catecholamine synthesis, to treat vasoplegia refractory to epinephrine, vasopressin, and norepinephrine after surgery requiring cardiopulmonary bypass. Reductions in vasopressor requirements were observed in all 3 patients, and, in 2 patients, norepinephrine was completely discontinued within 24 hours. Ascorbic acid is a novel potential therapeutic option for cardiac vasoplegia that warrants rigorous prospective studies.

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