• World Neurosurg · Nov 2018

    Review

    Towards Molecular Classification of Meningioma: Evolving Treatment and Diagnostic Paradigms.

    • Dustin T Proctor, Sudheesh Ramachandran, Sanju Lama, and Garnette R Sutherland.
    • Project neuroArm, Department of Clinical Neurosciences, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada; Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada; Arnie Charbonneau Cancer Institute, University of Calgary, Calgary, Alberta, Canada.
    • World Neurosurg. 2018 Nov 1; 119: 366-373.

    AbstractMeningioma, a common primary brain tumor in adults, is graded based on World Health Organization criteria that rely on histology alone. This approach is unable to determine conclusively which tumors, especially benign or atypical, will recur. Molecular characterization of meningioma has identified genetic biomarkers that can predict tumor behavior. Only a few genetic changes are known to classify >85% of all meningioma and clinical trials using targeted therapy to genetic subtypes of meningioma are under way. Immunotherapy is also being trialed in treating high-grade and recurrent meningioma. This review summarizes recent developments characterizing meningioma using genetic and immunologic biomarkers and how these molecular tools may be integrated into existing care together with current World Health Organization grading to improve diagnosis, prognosis, and therapy.Copyright © 2018 Elsevier Inc. All rights reserved.

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