• Hai-ping Pei, Hua Ge, Rui Jiang, and Hong Zhu.
• Department of Gastrointestinal Surgery, Central South University, Changsha 410008, China. gkh1115@126.com
• Zhonghua Wei Chang Wai Ke Za Zhi. 2010 Mar 1; 13 (3): 213-5.

ObjectiveTo investigate the expression of 14-3-3 sigma and heat shock protein 27 (HSP27) in colorectal carcinoma(CRC) tissue and its clinical significance.MethodsThe expression of 14-3-3 sigma and HSP27 was detected by immunohistochemical staining in 50 pathologically verified CRC cases. The association of clinical data with 14-3-3 sigma and HSP27 expression was examined.ResultsThe positive expression rate of 14-3-3 sigma was 10% in normal control mucosa and 58% in CRC tissue (P<0.01). The positive expression rate of HSP27 was 16% in normal control mucosa and 54% in CRC tissue (P<0.01). No correlation between 14-3-3 sigma and HSP27 expression was found in CRC tissue (P>0.05). The expression of 14-3-3 sigma was associated with patient age, tumor diameter and lymph node metastasis (LNM) (P<0.05), but not with gender, tumor differentiation or serous membrane invasion (P>0.05). The expression of HSP27 was associated with LNM (P<0.05), but not with gender, age, differentiation, tumor diameter or serous membrane invasion (P>0.05).ConclusionThe abnormal expression of 14-3-3 sigma and HSP27 is significantly associated with LNM in CRC.

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