• Best Pract Res Clin Anaesthesiol · Mar 2016

    Review

    Non-opioid analgesics: Novel approaches to perioperative analgesia for major spine surgery.

    • Lauren K Dunn, Marcel E Durieux, and Edward C Nemergut.
    • Department of Anesthesiology, University of Virginia, Charlottesville, VA 22903, USA. Electronic address: lak3r@hscmail.mcc.virginia.edu.
    • Best Pract Res Clin Anaesthesiol. 2016 Mar 1; 30 (1): 79-89.

    AbstractPerioperative pain management is a significant challenge following major spine surgery. Many pathways contribute to perioperative pain, including nociceptive, inflammatory, and neuropathic sources. Although opioids have long been a mainstay for perioperative analgesia, other non-opioid therapies have been increasingly used as part of a multimodal analgesic regimen to provide improved pain control while minimizing opioid-related side effects. Here we review the evidence supporting the use of novel analgesic approaches as an alternative to intravenous opioids for major spine surgery. Copyright © 2015 Elsevier Ltd. All rights reserved.

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