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- Marcello Di Nisio, Iris Wichers, and Saskia Middeldorp.
- Amsterdam Cardiovascular Sciences, University of Amsterdam, Amsterdam, the Netherlands.
- JAMA. 2018 Dec 11; 320 (22): 2367-2368.
Clinical QuestionWhich treatments for lower extremity superficial thrombophlebitis (ST) are associated with lower rates of venous thromboembolic events (VTEs) vs placebo?Bottom LineA dose of 2.5 mg of fondaparinux administered subcutaneously once daily for 45 days is associated with fewer cases of symptomatic VTE without an increase in major bleeding vs placebo. Low-molecular-weight heparin (LMWH) and nonsteroidal anti-inflammatory drugs (NSAIDs) are associated with lower rates of ST extension or recurrence vs placebo, but data regarding symptomatic VTE remain inconclusive. Oral rivaroxaban requires further evaluation.
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