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- Gin S Malhi and J John Mann.
- Department of Academic Psychiatry, Sydney Medical School Northern, University of Sydney, Sydney, NSW, Australia; CADE Clinic, Royal North Shore Hospital, Sydney, NSW, Australia. Electronic address: gin.malhi@sydney.edu.au.
- Lancet. 2018 Nov 24; 392 (10161): 2299-2312.
AbstractMajor depression is a common illness that severely limits psychosocial functioning and diminishes quality of life. In 2008, WHO ranked major depression as the third cause of burden of disease worldwide and projected that the disease will rank first by 2030.1 In practice, its detection, diagnosis, and management often pose challenges for clinicians because of its various presentations, unpredictable course and prognosis, and variable response to treatment.Copyright © 2018 Elsevier Ltd. All rights reserved.
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