• Paediatric anaesthesia · Jul 2012

    Early experiences of vasodilators and hypotensive anesthesia in children.

    • T C K Brown.
    • (Formerly) Royal Childrens Hospital, Melbourne, Victoria, Australia. tckbrown@netspace.net.au
    • Paediatr Anaesth. 2012 Jul 1;22(7):720-2.

    AbstractThe physiological application of OHMS LAW explains the basis of hypotensive anesthesia. V = IR translates into: Pressure = Flow × Resistance or Blood pressure = Cardiac Output × Peripheral Resistance. If peripheral resistance is reduced by a vasodilator such as sodium nitroprusside (a short acting, vascular smooth muscle relaxant) or phenoxybenzamine (a long acting α adrenoreceptor antagonist), blood pressure will fall and vasoconstriction and bleeding will be reduced. A less desirable alternative to lowering blood pressure could be to reduce cardiac output by suppressing myocardial contractility using a ß(1) adrenoceptor antagonist or an inhalational agent such as isoflurane.© 2012 Blackwell Publishing Ltd.

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