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- Dennis M Williams and Bruce K Rubin.
- University of North Carolina Eshelman School of Pharmacy, Chapel Hill, North Carolina.
- Respir Care. 2018 Jun 1; 63 (6): 641-654.
AbstractObstructive lung diseases, including asthma and COPD, are characterized by air-flow limitation. Bronchodilator therapy can often decrease symptoms of air-flow obstruction by relaxing airway smooth muscle (bronchodilation), decreasing dyspnea, and improving quality of life. In this review, we discuss the pharmacology of the β agonist and anticholinergic bronchodilators and their use, particularly in asthma and COPD. Expanding knowledge of receptor subtypes and G-protein signaling, agonist and antagonist specificity, and drug delivery have led to the introduction of safer medications with fewer off-target effects, medications with longer duration of action that may improve adherence, and more effective and efficient aerosol delivery devices.Copyright © 2018 by Daedalus Enterprises.
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