Genome-wide association study in a Chinese Han population

Nature genetics · Nov 2009

Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus.

We performed a genome-wide association study (GWAS) of systemic lupus erythematosus (SLE) in a Chinese Han population by genotyping 1,047 cases and 1,205 controls using Illumina Human610-Quad BeadChips and replicating 78 SNPs in two additional cohorts (3,152 cases and 7,050 controls). We identified nine new susceptibility loci (ETS1, IKZF1, RASGRP3, SLC15A4, TNIP1, 7q11.23, 10q11.22, 11q23.3 and 16p11.2; 1.77 x 10(-25) < or = P(combined) < or = 2.77 x 10(-8)) and confirmed seven previously reported loci (BLK, IRF5, STAT4, TNFAIP3, TNFSF4, 6q21 and 22q11.21; 5.17 x 10(-42) < or = P(combined) < or = 5.18 x 10(-12)). Comparison with previous GWAS findings highlighted the genetic heterogeneity of SLE susceptibility between Chinese Han and European populations. This study not only advances our understanding of the genetic basis of SLE but also highlights the value of performing GWAS in diverse ancestral populations.

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- Jian-Wen Han, Hou-Feng Zheng, Yong Cui, Liang-Dan Sun, Dong-Qing Ye, Zhi Hu, Jin-Hua Xu, Zhi-Ming Cai, Wei Huang, Guo-Ping Zhao, Hong-Fu Xie, Hong Fang, Qian-Jin Lu, Jian-Hua Xu, Xiang-Pei Li, Yun-Feng Pan, Dan-Qi Deng, Fan-Qin Zeng, Zhi-Zhong Ye, Xiao-Yan Zhang, Qing-Wen Wang, Fei Hao, Li Ma, Xian-Bo Zuo, Fu-Sheng Zhou, Wen-Hui Du, Yi-Lin Cheng, Jian-Qiang Yang, Song-Ke Shen, Jian Li, Yu-Jun Sheng, Xiao-Xia Zuo, Wei-Fang Zhu, Fei Gao, Pei-Lian Zhang, Qing Guo, Bo Li, Min Gao, Feng-Li Xiao, Cheng Quan, Chi Zhang, Zheng Zhang, Kun-Ju Zhu, Yang Li, Da-Yan Hu, Wen-Sheng Lu, Jian-Lin Huang, Sheng-Xiu Liu, Hui Li, Yun-Qing Ren, Zai-Xing Wang, Chun-Jun Yang, Pei-Guang Wang, Wen-Ming Zhou, Yong-Mei Lv, An-Ping Zhang, Sheng-Quan Zhang, Da Lin, Yi Li, Hui Qi Low, Min Shen, Zhi-Fang Zhai, Ying Wang, Feng-Yu Zhang, Sen Yang, Jian-Jun Liu, and Xue-Jun Zhang.
- Nat. Genet. 2009 Nov 1; 41 (11): 1234-7.
AbstractWe performed a genome-wide association study (GWAS) of systemic lupus erythematosus (SLE) in a Chinese Han population by genotyping 1,047 cases and 1,205 controls using Illumina Human610-Quad BeadChips and replicating 78 SNPs in two additional cohorts (3,152 cases and 7,050 controls). We identified nine new susceptibility loci (ETS1, IKZF1, RASGRP3, SLC15A4, TNIP1, 7q11.23, 10q11.22, 11q23.3 and 16p11.2; 1.77 x 10(-25) < or = P(combined) < or = 2.77 x 10(-8)) and confirmed seven previously reported loci (BLK, IRF5, STAT4, TNFAIP3, TNFSF4, 6q21 and 22q11.21; 5.17 x 10(-42) < or = P(combined) < or = 5.18 x 10(-12)). Comparison with previous GWAS findings highlighted the genetic heterogeneity of SLE susceptibility between Chinese Han and European populations. This study not only advances our understanding of the genetic basis of SLE but also highlights the value of performing GWAS in diverse ancestral populations.

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Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus.

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