• Philip A Cook, Thomas M Johnson, Suzanne G Martin, Philip R Gehrman, Seema Bhatnagar, and James C Gee.
• 1 University of Pennsylvania Perelman School of Medicine , Philadelphia, Pennsylvania.
• J. Neurotrauma. 2018 Apr 15; 35 (8): 991-1002.

AbstractTraumatic Brain Injury (TBI) has been described as the "signature injury" of the Global War on Terror. Explosive blast TBI has become a leading cause of injury as a result of the widespread use of improvised explosive devices in Iraq and Afghanistan. We present a retrospective cross-sectional study of patients with blast-related mild TBI (mTBI, N = 303) seen at the Intrepid Spirit Concussion Recovery Center at Naval Medical Center Camp Lejeune. The objective was to predict outcomes of return to duty (RTD) vs. medical retirement via medical evaluation board (MEB), based on brain imaging, neuropsychological data, and history of mTBI. The motivation is to inform prognosis and target resources to improve outcomes for service members who are less likely to RTD through the standard treatment program. The RTD was defined operationally as individuals who completed treatment and were not recommended for medical retirement or separation for TBI or related sequelae. Higher scores on the Repeatable Battery for Neuropsychological Status (RBANS) test were associated positively with RTD (p = 0.001). A history of three or more lifetime concussions was associated negatively with RTD, when compared with one concussion (p = 0.04). Elevated apparent diffusion coefficient (ADC) in the anterior corona radiata was associated negatively with RTD (p = 0.04). A logistic regression model was used to classify individuals with RBANS and imaging data (n = 81) as RTD or MEB according to RBANS, ADC, and a history of multiple (≥3) concussions. The RBANS (p = 0.003) and multiple concussions (p = 0.03) were significant terms in the logistic model, but ADC was not (p = 0.27). The area under the receiver operating characteristic curve was 0.77 (95% confidence interval 0.66-0.86). These results suggest cognitive testing and TBI history might be used to identify service members who are more likely to be retired medically from active duty.

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