• Michal Ivry, David Goitein, Wiam Welly, and Haim Berkenstadt.
• Department of Anesthesiology, Sheba Medical Center, Tel Hashomer, Ramat Gan, Israel. Affiliated with Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel. Electronic address: michal.ivry@sheba.health.gov.il.
• Surg Obes Relat Dis. 2017 Mar 1; 13 (3): 502-506.

BackgroundMelatonin has hypnotic, sedative, analgesic, anti-inflammatory, and antioxidant properties, and is a widely used sleep agent.ObjectivesOur aim was to evaluate the effect of melatonin premedication on postoperative recovery in patients undergoing bariatric surgery.SettingUniversity Hospital, Israel.MethodsPatients undergoing bariatric surgery were randomized to receive either 5 mg melatonin (M group) or placebo (P group) once on the night before surgery and again 2 hours before surgery. Quality of recovery was assessed using the QoR-15, a 15 item questionnaire on quality of recovery after surgery and anesthesia, regarding emotional state, physical comfort, psychological support, pain, and physical independence. A maximal score of 140 suggested good recovery (1 question was omitted due to irrelevance). The patients answered the questionnaire in the preanesthesia clinic, on admission to the operating room, and on the first postoperative day.ResultsA total of 44 patients completed the study. There was no statistical difference between M and P groups in the mean QoR-15 scores obtained before the surgery. Mean postoperative QoR-15 score was higher in the M group compared with the P group (118.3±12.9 versus 107.8±18.7, respectively; P<.01). Scores were also higher in the M group regarding pain (P<.05) and quality of sleep (P< .05).ConclusionsUse of melatonin premedication improved the quality of recovery 1 day after bariatric surgery as measured by the QoR-15, specifically the quality of sleep and pain levels. Melatonin may serve as a premedication, especially when other options, like benzodiazepines are not recommended.Copyright © 2017 American Society for Bariatric Surgery. Published by Elsevier Inc. All rights reserved.

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