• Arq Neuropsiquiatr · Oct 2013

    Nearly one-half of Brazilian patients with multiple sclerosis using natalizumab are DNA-JC virus positive.

    • Yara Dadalti Fragoso, Maria Fernanda Mendes, Walter Oleschko Arruda, Jefferson Becker, Joseph Bruno Bidin Brooks, Carvalho Margarete de Jesus Mde J, Elizabeth Regina Comini-Frota, Renan Barros Domingues, Maria Lucia Brito Ferreira, Alessandro Finkelsztejn, Paulo Diniz da Gama, Sidney Gomes, Marcus Vinicius Magno Gonçalves, Damacio Ramon Kaimen-Maciel, Rogério de Rizo Morales, Andre Muniz, Heloisa Helena Ruocco, Pedro Rippel Salgado, Livia Brito Bezerra de Albuquerque, Rodrigo Assad Diniz da Gama, Sergio Georgeto, Josiane Lopes, Celso Luis Silva Oliveira, Francisco Tomaz Meneses Oliveira, Juliana Safanelli, Patricia Correia de Oliveira Saldanha, and Massaco Satomi.
    • Universidade Metropolitana de Santos, SantosSP, Brasil.
    • Arq Neuropsiquiatr. 2013 Oct 1; 71 (10): 780-2.

    ObjectiveNatalizumab is a new and efficient treatment for multiple sclerosis (MS). The risk of developing progressive multifocal leukoencephalopathy (PML) during the use of this drug has created the need for better comprehension of JC virus (JCV) infection. The objective of the present study was to assess the prevalence of JCV-DNA in Brazilian patients using natalizumab.MethodQualitative detection of the JCV in the serum was performed with real-time polymerase chain reaction (PCR).ResultsIn a group of 168 patients with MS who were undergoing treatment with natalizumab, JCV-DNA was detectable in 86 (51.2%) patients.DiscussionData on JCV-DNA in Brazil add to the worldwide assessment of the prevalence of the JCV in MS patients requiring treatment with natalizumab.

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