• Congenital heart disease · Jan 2012

    Review

    Can "inoperable" congenital heart defects become operable in patients with pulmonary arterial hypertension? Dream or reality?

    • Maurice Beghetti, Nazzareno Galiè, and Damien Bonnet.
    • Pediatric Cardiology Unit, Department of the Child and Adolescent, Children's University Hospital, 6 Rue Willy Donzé, Geneva, Switzerland. maurice.beghetti@hcuge.ch
    • Congenit Heart Dis. 2012 Jan 1; 7 (1): 3-11.

    AbstractThe decision whether to repair congenital heart defects in patients with raised pulmonary vascular resistance to alleviate pulmonary hypertension is a complex one. The degree of pulmonary vascular disease is of paramount importance. Operating on patients with pulmonary vascular resistance above a certain threshold runs the risk of postoperative persistent pulmonary hypertension and a worse long-term prognosis. This review focuses on patients deemed "borderline inoperable" or "inoperable" due to pulmonary vascular disease and asks whether they can be "converted to an operable status" with pulmonary arterial hypertension-specific drugs that potentially modify the pulmonary vascular lesions and resistance.© 2012 Wiley Periodicals, Inc.

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