• Hannah M Timlin, Sarah A Carnaffin, Ian R Starkey, David B Northridge, and Stephen J Leslie.
• Department of Cardiology, University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh, Scotland, United Kingdom EH5 3NY.
• J Invasive Cardiol. 2005 Aug 1; 17 (8): 406-8.

ObjectiveTo assess the effect of long-acting local anesthetic (levobupivacaine) in addition to lidocaine for the management of femoral artery sheaths during and after percutaneous coronary intervention (PCI).BackgroundFemoral artery sheaths are commonly used during PCI. Sheath removal is often delayed after the procedure by which time short-acting local anesthetic agents may no longer be effective.MethodsSixty patients were randomized to either usual care or the administration of local levobupivacaine after PCI. Patients were asked to report their pain experienced on a visual analogue score.ResultsThirty patients received additional levobupivacaine (0.5%) and 30 received standard care. There were no procedural differences between the groups, except that more patients in the control group received intravenous (IV) morphine at the time of sheath removal. There was no difference between the control group and levobupivacaine group in pain scores at the time of sheath insertion. (2.0 +/- 0.4 versus 1.8 +/- 0.3; p = 0.80). Both groups recorded low pain scores while waiting for sheath removal, and the score was slightly (but not significantly) lower in the levobupivacaine group (1.3 +/- 0.2 versus 0.8 +/- 0.2; p = 0.09). Pain scores were lower in the levobupivacaine group during sheath removal 2.2 +/- 0.4 versus 1.1 +/- 0.2; p = 0.02). There were no differences in terms of blood pressure between the groups at any time point.ConclusionsLevobupivacaine reduced the need for IV opiate and provided better analgesia than lidocaine alone in patients undergoing PCI.

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