• Monique L Anderson, Graham Nichol, David Dai, Paul S Chan, Laine Thomas, Sana M Al-Khatib, Robert A Berg, Steven M Bradley, Eric D Peterson, and American Heart Association’s Get With the Guidelines–Resuscitation Investigators.
• Duke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina.
• JAMA Cardiol. 2016 Apr 1; 1 (1): 37-45.

ImportanceSurvival rates after in-hospital cardiac arrest (IHCA) vary significantly among US centers; whether this variation is owing to differences in IHCA care quality is unknown.ObjectiveTo evaluate hospital-level variation to determine whether hospital process composite performance measures of IHCA care quality are associated with patient outcomes.Design, Setting, And ParticipantsUsing data from the American Heart Association's Get With the Guidelines-Resuscitation (GWTG-R) program, we analyzed 35 283 patients 18 years or older with IHCA treated at 261 US hospitals from January 1, 2010, through December 31, 2012. We calculated the hospital process composite performance score for IHCA using 5 guideline-recommended process measures. Opportunity-based scores were calculated for all patients, aggregated at the hospital level, divided into quartiles, and then associated with risk-standardized survival and neurologic status by a test for trend. The scores were then evaluated through hierarchical logistic regression and reported as odds ratios per 10% increment in hospital process composite performance.InterventionsAcute care treatments for IHCA.Main Outcomes And MeasuresThe primary outcome was survival to discharge measured as risk standard survival rates, and the secondary outcome was favorable neurologic status at hospital discharge.ResultsOf the 35 283 adults included in this study, the median age was 67 years (interquartile range [IQR] 56-78 years), and 57.9% were male. The median IHCA hospital process composite performance was 89.7% (interquartile range, 85.4%-93.1%) and varied among hospital quartiles from 82.6% (lowest) to 94.8% (highest). The IHCA hospital process composite performance was linearly associated with risk-standardized hospital survival to discharge rates: 21.1%, 21.4%, 22.8%, and 23.4% from lowest to highest performance quartiles, respectively (P < .001). After adjustment, each 10% increase in a hospital's process composite performance was associated with a 22% higher odds of survival (adjusted odds ratio, 1.22; 95% CI, 1.08-1.37; P = .01). Hospital process composite quality performance was also associated with favorable neurologic status at discharge (P = .004).Conclusions And RelevanceThe quality of guideline-based care for IHCA varies significantly among US hospitals and is associated with patient survival and neurologic outcomes.

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