• Márcio Luiz Ferreira de Camillis, Augusto Savi, Goulart Rosa Regis R Intensive Care Unit, Hospital Moinhos de Vento, Porto Alegre, Brazil., Mariana Figueiredo, Ricardo Wickert, Borges Luis Guilherme Alegretti LGA Intensive Care Unit, Hospital Moinhos de Vento, Porto Alegre, Brazil., Lucas Galant, and Cassiano Teixeira.
• Intensive Care Unit, Hospital Moinhos de Vento, Porto Alegre, Brazil.
• Respir Care. 2018 Dec 1; 63 (12): 1471-1477.

BackgroundFew studies have evaluated the effects of mechanical insufflation-exsufflation (MI-E) in subjects on mechanical ventilation. Therefore, this study aimed to evaluate the effectiveness of MI-E on airway mucus clearance among mechanically ventilated ICU subjects.MethodsA randomized, parallel-group, open-label trial was conducted between June and November 2017 in a single, mixed ICU. Adult ICU subjects receiving mechanical ventilation for > 24 h with stable ventilatory and hemodynamic status were randomized to receive either standard respiratory physiotherapy alone (control group) or respiratory physiotherapy by using an MI-E device (intervention group). The primary outcome was the weight of aspirated airway mucus after study interventions. Secondary outcomes included variation in static lung compliance (ΔCL), airway resistance (ΔRaw), work of breathing (ΔWOB) in relation to the pre-intervention period, and hemodynamic and ventilator complications during the procedures.ResultsThere were 90 subjects in each group. The mean ± SD weight of the aspirated airway mucus was higher in the intervention group than in the control group (2.42 ± 2.32 g vs 1.35 ± 1.56 g, P < .001). The ΔCL values in the intervention group were higher than those in the control group (1.76 ± 4.90 mL/cm H2O vs -0.57 ± 4.85 mL/cm H2O, P = .001). The ΔRaw and ΔWOB values were similar between the groups. No hemodynamic or ventilatory complications were observed.ConclusionsAmong the general ICU subjects receiving mechanical ventilation, use of an MI-E device during respiratory physiotherapy resulted in a larger amount of airway mucus clearance than respiratory physiotherapy alone. (ClinicalTrials.gov registration NCT03178565.).Copyright © 2018 by Daedalus Enterprises.

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