• Rikke Neess Pedersen, Elisa Calzolari, Steffen Husby, Ester Garne, and EUROCAT Working group.
• Department of Pediatrics, Odense University Hospital, Odense, Denmark. rnp@dadlnet.dk
• Arch. Dis. Child. 2012 Mar 1; 97 (3): 227-32.

ObjectiveTo describe prevalence, prenatal diagnosis and epidemiological data on oesophageal atresia from 23 well-defined European regions and compare the prevalence between these regions.DesignPopulation-based study using data from a large European database for surveillance of congenital anomalies (EUROCAT) for two decades (1987-2006).SettingsTwenty-three participating registries based on multiple sources of information including information about live births, fetal deaths with gestational age ≥20 weeks and terminations of pregnancy.Patients1222 cases of oesophageal atresia in a population of 5 019 804 births.ResultsThe overall prevalence was 2.43 cases per 10 000 births (95% CI 2.30 to 2.57). There were regional differences in prevalence ranging from 1.27 to 4.55. Prenatal detection rates varied by registry from >50% of cases to <10% of cases. A total of 546 cases (44.7%) had an isolated oesophageal anomaly, 386 (31.6%) were multiple malformed and 290 (23.7%) had an association or a syndrome. There were 1084 live born cases (88.7%), 43 cases were fetal deaths and 95 cases were terminations of pregnancy. One-week survival for live births was 86.9% and 99.2% if the gestational age was ≥38 weeks and isolated oesophageal atresia was present. Males accounted for 57.3% of all cases and 38.5% of live born cases were born with gestational age <37 weeks.ConclusionThere were regional differences in prevalence of oesophageal atresia in Europe. Half of all cases had associated anomalies. Prenatal detection rate increased from 26% to 36.5% over the two decades. Survival in infants with isolated oesophageal atresia born at term is high.

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