• Alireza M Mohammadi, Mayur Sharma, Thomas L Beaumont, Kevin O Juarez, Hanna Kemeny, Cosette Dechant, Andreas Seas, Nehaw Sarmey, Bryan S Lee, Xuefei Jia, Peter E Fecci, Joachim Baehring, Jennifer Moliterno, Veronica L Chiang, Manmeet S Ahluwalia, Albert H Kim, Gene H Barnett, and Eric C Leuthardt.
• The Rose Ella Burkhardt Brain Tumor and Neuro-Oncology Center, Department of Neurosurgery, Neurological Institute, Cleveland Clinic Lerner College of Medicine, Cleveland, Ohio.
• Neurosurgery. 2019 Dec 1; 85 (6): 762-772.

BackgroundLaser ablation (LA) is used as an upfront treatment in patients with deep seated newly diagnosed Glioblastoma (nGBM).ObjectiveTo evaluate the outcomes of LA in patients with nGBM and compare them with a matched biopsy-only cohort.MethodsTwenty-four nGBM patients underwent upfront LA at Cleveland clinic, Washington University in St. Louis, and Yale University (6/2011-12/2014) followed by chemo/radiotherapy. Also, 24 out of 171 nGBM patients with biopsy followed by chemo/radiotherapy were matched based on age (< 70 vs ≥ 70), gender, tumor location (deep vs lobar), and volume (<11 cc vs ≥11 cc). Progression-free survival (PFS), overall survival (OS), and disease-specific PFS and OS were outcome measures. Three prognostic groups were identified based on extent of tumor ablation by thermal-damage-threshold (TDT)-lines.ResultsThe median tumor volume in LA (n = 24) and biopsy only (n = 24) groups was 9.3 cm3 and 8.2 cm3 respectively. Overall, median estimate of OS and PFS in LA cohort was 14.4 and 4.3 mo compared to 15.8 mo and 5.9 mo for biopsy only cohort. On multivariate analysis, favorable TDT-line prognostic groups were associated with lower incidence of disease specific death (P = .03) and progression (P = .05) compared to other groups including biopsy only cohort. Only age (<70 yr, P = .02) and tumor volume (<11 cc, P = .03) were favorable prognostic factors for OS.ConclusionThe maximum tumor coverage by LA followed by radiation/chemotherapy is an effective treatment modality in patients with nGBM, compared to biopsy only cohort. The TDT-line prognostic groups were independent predictor of disease specific death and progression after LA.Copyright © 2018 by the Congress of Neurological Surgeons.

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