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- Linda A DiMeglio, Carmella Evans-Molina, and Richard A Oram.
- Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, USA. Electronic address: dimeglio@iu.edu.
- Lancet. 2018 Jun 16; 391 (10138): 244924622449-2462.
AbstractType 1 diabetes is a chronic autoimmune disease characterised by insulin deficiency and resultant hyperglycaemia. Knowledge of type 1 diabetes has rapidly increased over the past 25 years, resulting in a broad understanding about many aspects of the disease, including its genetics, epidemiology, immune and β-cell phenotypes, and disease burden. Interventions to preserve β cells have been tested, and several methods to improve clinical disease management have been assessed. However, wide gaps still exist in our understanding of type 1 diabetes and our ability to standardise clinical care and decrease disease-associated complications and burden. This Seminar gives an overview of the current understanding of the disease and potential future directions for research and care.Copyright © 2018 Elsevier Ltd. All rights reserved.
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