• Judith I Tsui, Marlene C Lira, Debbie M Cheng, Michael R Winter, Daniel P Alford, Jane M Liebschutz, Robert R Edwards, and Jeffrey H Samet.
• Section of General Internal Medicine, Department of Medicine, Harborview Hospital/University of Washington School of Medicine, 325 9th Avenue, Box 359780, Seattle, WA 98104, United States. Electronic address: tsuij@uw.edu.
• Drug Alcohol Depend. 2016 Sep 1; 166: 26-31.

AimsIn a sample of patients receiving opioid agonist therapy, we evaluated whether having chronic pain was associated with (a) craving for opioids and (b) illicit opioid use.MethodsIn a cross-sectional study of adults on buprenorphine or methadone maintenance recruited from an urban medical center, we examined any craving for opioids (primary dependent variable) in the past week and recent illicit opioid use (secondary dependent variable). Illicit opioid use was defined as a positive urine drug test (UDT) for opiates and chronic pain was defined as bodily pain that had been present for at least 3 months. Multivariable logistic regression models were fit for each outcome, adjusting for age, sex, and non-white race. Additional models adjusted for depression (PHQ-9) and anxiety (STAI).ResultsThe sample included 105 adults on methadone or buprenorphine maintenance. Mean age was 43.8 (SD ±9.4)years; 48% were female and 32% non-white; 19% were on methadone. Chronic pain was present in 68% of the sample, 51% reported craving opioids in the past week, and 16% had a positive UDT. Chronic pain was associated with 3-fold higher odds of reporting craving in the past week (aOR=3.10; 95% CI: 1.28-7.50, p-value=0.01). The relative odds for having a positive UDT were not statistically significant (aOR=2.52; 95% CI: 0.64-9.90, p=0.18).ConclusionIn this sample of patients treated with opioid agonist therapy, those with chronic pain had higher odds of reporting craving for opioids. Chronic pain with associated opioid craving potentially places this population at risk for relapse.Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

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