• Qi Jia, Chao Liu, Jian Yang, Huabin Yin, Jian Zhao, Haifeng Wei, Tielong Liu, Xinghai Yang, Cheng Yang, Zhenhua Zhou, and Jianru Xiao.
• Department of Orthopedic Oncology, Changzheng Hospital, Second Military Medical University, Shanghai, China.
• Neurosurgery. 2020 Jan 1; 86 (1): 71-79.

BackgroundOsteoblastoma (OBL) in the mobile spine is a benign tumor with aggressive potential. There is not much published information on OBL of the mobile spine as a result of rarity of the disease. There are controversies over the aggressive subtype and prognostic factors of the condition.ObjectiveTo explore the aggressive subtype and investigate prognostic factors of OBLs in the mobile spine.MethodsA retrospective analysis of spinal OBL was performed by survival analysis. Patients in 2 cohorts were analyzed based on the Enneking grade and pathological evaluation. Local recurrence-free survival (RFS) was estimated using the Kaplan-Meier method to identify potential prognostic factors. Factors with P ≤ .05 were subjected to multivariate analysis by Cox regression analysis. P ≤ .05 were considered statistically significant.ResultsIncluded in this study were 70 patients with spinal OBL who were followed up by a mean of 67.1 mo (range 24-188). Local recurrence was detected in 9 cases after initial surgery, and death occurred in 2 cases. The result of statistical analysis suggested that Epithelioid OBL (EO) with Enneking stage 3 (St.3) and total spondylectomy were independent prognostic factors for RFS.ConclusionSt.3 or EO lesions seem to be more aggressive than St.2 or conventional osteoblastomas, but St.3 and EO should be considered simultaneously in predicting the aggressiveness of the lesion and the risk of recurrence. Total spondylectomy performed either by en bloc or piecemeal could significantly reduce recurrence of OBLs in the mobile spine.Copyright © 2018 by the Congress of Neurological Surgeons.

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