• Daniel R Felling, Miles W Jackson, Jane Ferraro, Michael A Battaglia, Jeremy J Albright, Juan Wu, Cheryl K Genord, Kara K Brockhaus, Rohit A Bhave, Amanda M McClure, Beth-Ann Shanker, and Robert K Cleary.
• Department of Surgery, St Joseph Mercy Hospital, Ann Arbor, Michigan.
• Dis. Colon Rectum. 2018 Oct 1; 61 (10): 1196-1204.

BackgroundMultimodal pain management is an integral part of enhanced recovery pathways. The most effective pain management strategies have not been determined.ObjectiveThe purpose of this study was to compare liposomal bupivacaine transversus abdominis plane block with epidural analgesia in patients undergoing colorectal surgery.DesignThis is a single-institution, open-label randomized (1:1) trial.SettingThis study compared liposomal bupivacaine transversus abdominis plane block with epidural analgesia in patients undergoing elective open and minimally invasive colorectal surgery in an enhanced recovery pathway.PatientsTwo hundred were enrolled. Following randomization, allocation, and follow-up, there were 92 patients with transversus abdominis plane block and 87 patients with epidural analgesia available for analysis.InterventionsThe interventions comprised liposomal bupivacaine transversus abdominis plane block versus epidural analgesia.Main Outcome MeasuresThe primary outcomes measured were numeric pain scores and the overall benefit of analgesia scores.ResultsThere were no significant differences in the Numeric Pain Scale and Overall Benefit of Analgesia Score between groups. Time trend analysis revealed that patients with transversus abdominis plane block had higher numeric pain scores on the day of surgery, but that the relationship was reversed later in the postoperative period. Opioid use was significantly less in the transversus abdominis plane block group (206.84 mg vs 98.29 mg, p < 0.001). There were no significant differences in time to GI recovery, hospital length of stay, and postoperative complications. Cost was considerably more for the epidural analgesia group.LimitationsThis study was conducted at a single institution.ConclusionsThis randomized trial shows that perioperative pain management with liposomal bupivacaine transversus abdominis plane block is as effective as epidural analgesia and is associated with less opioid use and less cost. These data and the more favorable risk profile suggest that liposomal bupivacaine transversus abdominis plane block is a viable multimodal perioperative pain management option for this patient population in an established enhanced recovery pathway.Clinical Trial Registrationhttp://www.clinicaltrials.gov (NCT02591407). See Video Abstract at http://links.lww.com/DCR/A737.

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