• Xiang-Yang Bao, Qian-Nan Wang, Yong Zhang, Qian Zhang, De-Sheng Li, Wei-Zhong Yang, Zheng-Shan Zhang, Rui Zong, Cong Han, and Lian Duan.
• Department of Neurosurgery, The Center for Cerebral Vascular Disease, Academy of Military Medical Science, Beijing, China.
• World Neurosurg. 2019 Feb 1; 122: e917-e923.

BackgroundTo our knowledge, no previous study has described the nationwide epidemiologic features of moyamoya disease (MMD) in China. We describe the epidemiologic features including the relative prevalence, age distribution, gender distribution, and initial clinical manifestations of patients with MMD treated at a single institution in China.MethodsOur cohort included 4128 patients with MMD. Their demographic and clinical characteristics were obtained by retrospective chart review.ResultsThe median age for the onset of symptoms was 30.36 years. The age distribution of patients with MMD was bimodal, with the highest peak detection rate at 35-45 years of age and a smaller peak at 5-9 years of age. The ratio of female-to-male patients was 1:1. The disease occurred mainly in the Han people and was rarely seen in minority nationalities. In our cohort, transient ischemic attack was the most common initial clinical manifestation (48.13%). The other initial manifestations included infarction (22.62%), hemorrhage (16.45%), and headache 230/4128 (5.57%). In north and northeast China, the ischemic type was more predominate while the hemorrhagic type was relatively rare. However, the percentage of hemorrhagic type in East China was higher than anywhere else in China.ConclusionsThis study confirmed some unique epidemiologic features as the studies previously reported in China, but it also revealed some new sight and tendency about moyamoya in China. As a lack of national epidemiologic studies, this study indicated the outline of moyamoya in China.Copyright © 2018 Elsevier Inc. All rights reserved.

18 keywords...

hide…