• Rinsho Shinkeigaku · Nov 2017

    Case Reports

    [A case of anti-MOG antibody-positive multiphasic disseminated encephalomyelitis co-occurring with unilateral cerebral cortical encephalitis].

    • Naoya Fukushima, Miki Suzuki, Ryo Ogawa, Kitami Hayashi, Takanashi Jun-Ichi JI Division of Pediatric Neurology, Department of Pediatrics, Tokyo Women's Medical University Yachiyo Medical Center., and Takashi Ohashi.
    • Division of Neurology, Department of Internal Medicine, Tokyo Women's Medical University Yachiyo Medical Center.
    • Rinsho Shinkeigaku. 2017 Nov 25; 57 (11): 723-728.

    AbstractA 20-year-old woman first developed acute disseminated encephalomyelitis (ADEM) at 11 years of age. At 17 years of age, she was hospitalized due to generalized seizure and diagnosed with encephalitis. Brain MRI revealed a FLAIR-hyperintense lesion in the unilateral cerebral cortex. At 18 years of age, serum anti-myelin oligodendrocyte glycoprotein (MOG) antibody was detected. At 20 years of age, she was admitted to our hospital, diagnosed with multifocal disseminated encephalomyelitis (MDEM). MDEM has been observed in patients that are seropositive for the anti-MOG antibody. More recently, unilateral cerebral cortex encephalitis with epilepsy has also been reported in such patients. The co-occurrence of MDEM and cortical encephalitis in the same patient has important implications for the pathogenesis of anti-MOG antibody-associated autoimmune diseases.

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