• Ling-Xin Chen, Sevag Demirjian, Suneel M Udani, Sharon A Trevino, Patrick T Murray, and Jay L Koyner.
• Department of Medicine, Section of Transplant Nephrology, Division of Nephrology, University of California, Sacramento, California, USA.
• Blood Purif. 2018 Jan 1; 46 (4): 315-322.

Background/AimsWe sought to quantify any differences in cytokine clearance between continuous venovenous hemofiltration (CVVH-convective) compared to continuous venovenous hemodialysis (CVVHD-diffusive).MethodsWe conducted a 20 patient, multicenter, prospective, open-label randomized trial (CVVH or CVVHD) at continuous renal -replacement therapy (CRRT) initiation. Blood, urine, and effluent were collected at 0, 4, 24, and 48 h after initiation of CRRT. Serum electrolytes, cytokines levels, and clearances were measured. Cytokines studies included IL-1β, IL-1RA, IL-6, IL-10, and TNFα.ResultsWe randomized 20 patients to receive CRRT. After 4 h of CRRT there was no difference in total cytokine levels or change in cytokine concentrations across the 2 groups. With the exception of IL-1 RA, all cytokines levels decreased across patient groups regardless of modality. There was no significant difference in cytokine concentration across CRRT modality for any time point.ConclusionWithin the first 4 h of CRRT initiation, there is no significant difference between cytokine or solute clearance between CVVH and CVVHD.© 2018 S. Karger AG, Basel.

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