• ORL J. Otorhinolaryngol. Relat. Spec. · Mar 1993

    Nose drops induce vasomotion in the microcirculation of the sinus mucosa of the rabbit.

    • M Bende, K E Arfors, and M Intaglietta.
    • Department of Applied Mechanics, University of California, San Diego, La Jolla.
    • ORL J. Otorhinolaryngol. Relat. Spec. 1993 Mar 1; 55 (2): 110-3.

    AbstractPeriodic oscillations of blood in the microcirculation of the sinus mucosa in the rabbit were studied with laser-Doppler flowmetry after the application of nose drops (oxymetazoline, xylometazoline and phenylephrine) to the nasal mucosa. All of these drugs induced a dose-dependent decrease in the blood flow in the mucosa. Flowmotion was found in 9 of 21 experiments after an approximately 50% reduction in blood flow had been induced. The concentrations of the drugs which caused vasomotion corresponded to those normally administered as nose drops to man.

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