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- Victor A Chow, Mazyar Shadman, and Ajay K Gopal.
- Division of Medical Oncology, Department of Medicine, University of Washington, Seattle, WA.
- Blood. 2018 Aug 23; 132 (8): 777-781.
AbstractChimeric antigen receptor T cells demonstrate efficacy in B-cell malignancies, leading to US Food and Drug Administration approval of axicabtagene ciloleucel (October 2017) and tisagenlecleucel (May 2018) for large B-cell lymphomas after 2 prior lines of therapy. Durable remissions are seen in 30% to 40% of study-treated patients, but toxicities of cytokine release syndrome and neurotoxicity require administration in specialized centers. This article reviews data of current diffuse large B-cell lymphoma management, focusing on axicabtagene ciloleucel, tisagenlecleucel, and lisocabtagene maraleucel.© 2018 by The American Society of Hematology.
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