• Burns · Sep 2018

    Randomized Controlled Trial

    The efficacy of excision followed by intralesional 5-fluorouracil and triamcinolone acetonide versus excision followed by radiotherapy in the treatment of ear keloids: A randomized control trial.

    • Farrukh Aslam Khalid, Usman Khalid Farooq, Muhammad Saleem, Jibran Rabbani, Muhammad Amin, Kamal Uddin Khan, Younas Mehrose, and Moazzam N Tarar.
    • Jinnah Burn and Reconstructive Surgery Center, Allama Iqbal Medical College, Lahore, Pakistan; Children Reconstructive Surgery and Research Centre, Shalamar Hospital/Shalamar Medical College, Lahore, Pakistan. Electronic address: drfarrukhaslam@gmail.com.
    • Burns. 2018 Sep 1; 44 (6): 1489-1495.

    BackgroundThe ear is the common site for keloid formation especially in women after ear piercing. Surgery is the main stay of treatment in these lesions but there are large numbers of treatment failures in surgery alone.ObjectiveThe objective of this study was to compare the efficacy of post-excision intralesional 5-fluorouracil/triamcinolone acetonide (5-FU/TAC) and post-excision radiotherapy in the treatment of ear keloids.Study DesignA randomized controlled trial.SettingThe study was conducted from May 2014 to January 2015 at Jinnah Burn and Reconstructive Surgery Centre, Allama Iqbal Medical College, Lahore.Subject & MethodologyAfter approval from the hospital ethical committee, 60 patients presented in the outpatient department fulfilling the inclusion criteria were selected and randomly assigned in two groups with the help of the random number table. Patients in group A had excision followed by intralesional 5-FU/TAC injections while patients of group B had excision followed by radiotherapy. Patients were assessed at 6 months after completion of treatment for efficacy (no recurrence within 6 months of treatment).ResultsIn our study total of 60 patients completed the study, with 30 patients in each group. 7 patients (23.34%) in Group-A and 9 patients (30%) in Group-B were males while 23 patients (76.67%) in Group-A and 21 patients (70%) in Group-B were females i.e. male to female ratio is 1:2.75. Mean age was 31.8+6.48years. The comparison of frequency of efficacy in both groups showed that 73.33% (n=22) in Group-A and 43.33% (n=13) in Group-B had efficacy, p value was calculated as 0.01, showing a significant statistical difference.ConclusionExcision and intralesional 5-FU/TAC is an effective treatment for keloids on the ears.Copyright © 2018 Elsevier Ltd and ISBI. All rights reserved.

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