• Tessa Garside, Fiona M Wood, and Ann-Maree Vallence.
• Burn Injury Research Unit, University of Western Australia, Crawley, Western Australia, Australia. Electronic address: tessa.garside@health.nsw.gov.au.
• Burns. 2018 Aug 1; 44 (5): 1195-1202.

ObjectiveThe study aimed to investigate intracortical inhibition following a burn injury, and to establish transcranial magnetic stimulation (TMS) as a useful and sensitive tool to investigate the cortical response to a burn injury.MethodsThirteen burn injured patients and 12 uninjured subjects underwent TMS to measure the cortical silent period (cSP), a marker of intracortical inhibition.ResultsIn burn injury patients, cSP was similar in the burn-injured and less-injured arm (133 and 132ms respectively; p=0.96). cSP was numerically shorter in burns patients than control subjects, however, these differences were not statistically significant (133 vs 148ms, p=0.24). Subgroup analysis revealed cSP was shorter in the burn arm of patients compared to the uninjured control subjects in patients with upper-limb burn (cSP 120ms vs 148ms, p=0.03), those with <10% TBSA (cSP 120ms vs 148ms, p=0.01), those <2 years' post-burn (cSP 110ms vs 148ms, p=0.01), and patients with partial thickness burns (cSP 120ms vs 148ms, p=0.02).ConclusionsThese results demonstrate significantly shorter cSP in the burned arm in patients with upper limb burn sustained <2years ago, those with partial thickness burns, those with upper limb burns only, and those with burns of less than 10% TBSA. The results are consistent with the existing literature, which demonstrates a reduction in cSP duration in patients with a range of peripheral nerve injuries. There is a strong suggestion that cortical inhibition is altered following burn injury, and that TMS is a useful and sensitive method for investigating changes in cortical inhibition in burn patients.Copyright © 2018 Elsevier Ltd and ISBI. All rights reserved.

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