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- Lauren E Rotman, T Brooks Vaughan, James R Hackney, and Kristen O Riley.
- Department of Neurosurgery, University of Alabama at Birmingham, Birmingham, Alabama, USA. Electronic address: lerotman@uabmc.edu.
- World Neurosurg. 2019 Feb 1; 122: 417-423.
BackgroundPituitary carcinomas are rare and aggressive neoplasms that despite current treatment regimens continue to have a poor prognosis. Adrenocorticotrophic hormone pituitary tumors have been shown to alter their clinical manifestations with conversion to Cushing disease and silent types.Case DescriptionThe purpose of this paper is to present the first documented case of an adrenocorticotrophic hormone-secreting pituitary adenoma with Cushing disease that differentiated into a silent corticotroph pituitary carcinoma with metastases to distant sites in the central nervous system.ConclusionsThis patient was later treated with radiotherapy, temozolomide, and bevacizumab, with 8 years of progression-free survival.Copyright © 2018 Elsevier Inc. All rights reserved.
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