• Daisuke Shigemi, Shotaro Aso, Hiroki Matsui, Kiyohide Fushimi, and Hideo Yasunaga.
• Department of Clinical Epidemiology and Health Economics (Drs. Shigemi, Aso, Matsui, and Yasunaga), School of Public Health, The University of Tokyo, Tokyo, Japan. Electronic address: dshigemi@m.u-tokyo.ac.jp.
• J Minim Invasive Gynecol. 2019 Mar 1; 26 (3): 501-506.

Study ObjectiveTo compare fetal, maternal, and operative outcomes of laparoscopic surgery versus laparotomy for major benign diseases including appendicitis, cholecystitis, adnexal masses, and uterine myoma during pregnancy.DesignRetrospective cohort study (Canadian Task Force classification II-2).SettingThe Diagnosis Procedure Combination database, a national inpatient database for acute care inpatients in Japan.PatientsEligible patients (n = 6018) underwent abdominal surgery (4047 laparotomy and 1971 laparoscopy patients) from July 2010 through March 2016.InterventionsThe 2 groups were compared using propensity score matching analysis.Measurements And Main ResultsThe primary outcome was fetal adverse events, including abortion or stillbirth within 7 days after surgery and premature delivery during hospitalization. Secondary outcomes were operative time, blood transfusion, and length of hospital stay after surgery. Propensity score matching created 740 pairs. Significant difference was observed in the primary outcome between propensity score-matched patients in the laparotomy versus laparoscopy group (1.8% vs .41%, respectively; risk difference, -1.4%; 95% confidence interval, -2.4 to -.30; p = .01). Compared with the laparotomy group, the laparoscopy group had a significantly lower incidence of blood transfusion (2.3% vs .41%, p = .002), shorter operative time (115 vs 95 minutes, p <.001), and shorter hospital stay (9.2 vs 5.9 days, p <.001).ConclusionOur current study using propensity score matching suggests the advantages of laparoscopic surgery for benign diseases compared with laparotomy because laparoscopic surgery had advantages in short-term fetal adverse events, incidence of blood transfusion, operative time, and hospital stay.Copyright © 2018 AAGL. Published by Elsevier Inc. All rights reserved.

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