• ASAIO J. · Mar 2019

    Interpreting Neurologic Outcomes in a Changing Trial Design Landscape: An Analysis of HVAD Using a Hybrid Intention to Treat Population.

    • Claudius Mahr, Duc Thinh Pham, Nahush A Mokadam, Scott C Silvestry, Jennifer Cowger, Michael S Kiernan, David A D'alessandro, Erin E Coglianese, Muhammad Faraz Masood, Robert L Kormos, Mary V Jacoski, and Jeffrey J Teuteberg.
    • From the University of Washington, Seattle, Washington.
    • ASAIO J. 2019 Mar 1; 65 (3): 293-296.

    AbstractRandomized controlled trials can provide optimal clinical evidence to assess the benefits of new devices, and it is these data that often shape device usage in real-world practice. However, individual clinical trial results sometimes appear discordant for the same device, and alternative devices are sometimes not employed in similar patient populations. To make sound evidence-based decisions, clinicians routinely rely on cross-trial comparisons from different trials of similar but not identical patient populations to assess competing technology when head-to-head randomized comparisons are unavailable.

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