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J. Cardiovasc. Pharmacol. Ther. · Nov 2013
ReviewCardiovascular pharmacology core reviews: aspirin.
- Michael A Gaglia and Leonardo Clavijo.
- 1Division of Cardiovascular Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
- J. Cardiovasc. Pharmacol. Ther. 2013 Nov 1; 18 (6): 505-13.
AbstractAcetylsalicylic acid, or aspirin, is perhaps the most well-studied drug in human history, but controversy persists regarding both optimal dose and its use in the primary prevention of atherothrombotic events. This article reviews the following: the effect of aspirin upon the cyclooxygenase pathway; clinical trials of aspirin for both secondary and primary prevention; prospective and retrospective studies of aspirin dose; the potential interaction between aspirin and ticagrelor; and the concept of aspirin resistance. It concludes with a review of major society guidelines regarding aspirin and offers a perspective on the evidence-based use of aspirin in clinical practice.
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