• Mario Pelaez-Luna, Santhi Swaroop Vege, Bret T Petersen, Suresh T Chari, Jonathan E Clain, Michael J Levy, Randal K Pearson, Mark D Topazian, Michael B Farnell, Michael L Kendrick, and Todd H Baron.
• Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA.
• Gastrointest. Endosc. 2008 Jul 1; 68 (1): 91-7.

BackgroundInformation regarding the natural history, clinical characteristics, and outcomes of disconnected pancreatic duct syndrome (DPDS) is limited.ObjectiveTo describe clinical characteristics and outcomes of DPDS.DesignA retrospective review of the Mayo Clinic endoscopy and hospital service database.SettingTertiary-referral center.PatientsWe identified 31 DPDS cases from 1999 to 2006.InterventionsEndoscopic drainage of pancreatic-fluid collections.Main Outcome MeasurementsThe relationship between demographic and clinical data with endoscopic treatment and clinical outcomes in DPDS cases.ResultsThe median patient age was 53 years (range 20-83 years); 48% were men. The most common etiology of acute pancreatitis (AP) was biliary (55%) followed by idiopathic (27%). The median interval between the diagnoses of AP and DPDS was 56 days (range 3-251 days); the median follow-up after the last ERCP or surgical procedure was 7 months (range 0-90 months). The DPDS location included the following: pancreas head 6%, neck 58%, body 26%, and tail 10%. Twenty-six patients had initial endoscopic treatment (19 had long-term improvement; 7 failed treatment and required surgery) and 5 underwent immediate surgery. Mortality was 0%; 26% developed chronic pancreatitis (CP) and 16% diabetes mellitus (DM); 10% resolved completely, 45% had smaller fluid collections, and 26% patients were lost to follow-up. No relationship between demographic and clinical data with endoscopic and clinical outcomes was found.ConclusionsEndoscopic treatment temporarily improved DPDS, with a failure rate of 23%. Immediate surgery was not required in all cases. CP and/or pancreatic atrophy occurred relatively shortly after the DPDS diagnosis in 26% and DM in 16% of cases. DPDS did not lead to mortality. Early surgery may be considered after initially stabilizing the fluid collection with endoscopic therapy.

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