• Reem Z Sharaiha, Amy Tyberg, Mouen A Khashab, Nikhil A Kumta, Kunal Karia, Jose Nieto, Uzma D Siddiqui, Irving Waxman, Virendra Joshi, Petros C Benias, Peter Darwin, Christopher J DiMaio, Christopher J Mulder, Shai Friedland, David G Forcione, Divyesh V Sejpal, Tamas A Gonda, Frank G Gress, Monica Gaidhane, Ann Koons, Ersilia M DeFilippis, Sanjay Salgado, Kristen R Weaver, John M Poneros, Amrita Sethi, Sammy Ho, Vivek Kumbhari, Vikesh K Singh, Alan H Tieu, Viviana Parra, Alisa Likhitsup, Craig Womeldorph, Brenna Casey, Sreeni S Jonnalagadda, Amit P Desai, David L Carr-Locke, Michel Kahaleh, and Ali A Siddiqui.
• Gastroenterology and Hepatology, Weill Cornell Medical Center, New York, New York. Electronic address: rzs9001@med.cornell.edu.
• Clin. Gastroenterol. Hepatol. 2016 Dec 1; 14 (12): 1797-1803.

Background & AimsEndoscopic ultrasound-guided transmural drainage and necrosectomy have become the standard treatment for patients with pancreatic walled-off necrosis (WON). Lumen-apposing metal stents (LAMS) have shown success in the management of pancreatic fluid collections. However, there are few data on their specific roles in management of WON. We investigated the efficacy and safety of LAMS in treatment of WON.MethodsWe performed a retrospective multicenter case series of 124 patients with WON who underwent endoscopic transmural drainage by using LAMS at 17 tertiary care centers from January 2014 through May 2015. Patients underwent endoscopic ultrasound-guided cystogastrostomy or cystoenterostomy with placement of an LAMS into the WON collection. At the discretion of the endoscopist, we performed direct endoscopic necrosectomy, irrigation with hydrogen peroxide, and/or nasocystic drain placement. We performed endoscopic retrograde cholangiopancreatography with pancreatic duct stent placement when indicated. Concomitant therapies included direct endoscopic debridement (n = 78), pancreatic duct stent placement for leak (n = 19), hydrogen peroxide-assisted necrosectomy (n = 38), and nasocystic irrigation (n = 22). We collected data for a median time of 4 months (range, 1-34 months) after the LAMS placement. The primary outcomes were rates of technical success (successful placement of the LAMS), clinical success (resolution of WON, on the basis of image analysis, without need for further intervention via surgery or interventional radiology), and adverse events.ResultsThe median size of the WON was 9.5 cm (range, 4-30 cm). Eight patients had 2 LAMS placed for multiport access, all with technical success (100%). Clinical success was achieved in 107 patients (86.3%) after 3 months of follow-up. Thirteen patients required a percutaneous drain, and 3 required a surgical intervention to manage their WON. The stents remained patent in 94% of patients (117 of 124) and migrated in 5.6% of patients (7 of 124). The median number of endoscopic interventions was 2 (range, 1-9 interventions).ConclusionsOn the basis of a retrospective analysis of 124 patients, endoscopic therapy of WON by using LAMS is safe and effective. Creation of a large and sustained cystogastrostomy or cystoenterostomy tract is effective in the drainage and treatment of WON.Copyright © 2016 AGA Institute. Published by Elsevier Inc. All rights reserved.

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