• Frank J Attenello, Timothy Wen, Steven Y Cen, Alvin Ng, May Kim-Tenser, Nerses Sanossian, Arun P Amar, and William J Mack.
• Department of Neurosurgery, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
• BMJ. 2015 Jan 1;350:h1460.

ObjectiveTo evaluate the association between weekend admission to hospital and 11 hospital acquired conditions recently considered by the Centers for Medicare and Medicaid as "never events" for which resulting healthcare costs are not reimbursed.DesignNational analysis.SettingUS Nationwide Inpatient Sample discharge database.Participants351 million patients discharged from US hospitals, 2002-10.Main Outcome MeasuresUnivariate rates and multivariable likelihood of hospital acquired conditions among patients admitted on weekdays versus weekends, as well as the impacts of these events on prolonged length of stay and total inpatient charges.ResultsFrom 2002 to 2010, 351,170,803 patients were admitted to hospital, with 19% admitted on a weekend. Hospital acquired conditions occurred at an overall frequency of 4.1% (5.7% among weekend admissions versus 3.7% among weekday admissions). Adjusting for patient and hospital cofactors the probability of having one or more hospital acquired conditions was more than 20% higher in weekend admissions compared with weekday admissions (odds ratio 1.25, 95% confidence interval 1.24 to 1.26, P<0.01). Hospital acquired conditions have a negative impact on both hospital charges and length of stay. At least one hospital acquired condition was associated with an 83% (1.83, 1.77 to 1.90, P<0.01) likelihood of increased charges and 38% likelihood of prolonged length of stay (1.38, 1.36 to 1.41, P<0.01).ConclusionWeekend admission to hospital is associated with an increased likelihood of hospital acquired condition, cost, and length of stay. Future protocols and staffing regulations must be tailored to the requirements of this high risk subgroup.© Attenello et al 2015.

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