• Y Terada, S Inoue, M Konda, J Egawa, J Ueda, T Kirita, and M Kawaguchi.
• Department of Anesthesiology and Division of Intensive Care, Nara Medical University, Japan.
• Med Intensiva. 2019 Jan 1; 43 (1): 3-9.

ObjectiveCognitive impairment after intensive care unit (ICU) admission is becoming increasingly recognized. High-dose deep sedation has been suggested to play an important role in the development of cognitive impairment. However, the impact of heavy sedation as a single cause in the development of cognitive impairment in ICU patients remains unclear. In this study we investigated whether a three-day deep sedation protocol could reduce cognitive function in mechanically ventilated non-critical patients.DesignA prospective observational study was carried out.PatientsA total of 17 surgical patients were studied.InterventionNone.Variables Of InterestCognitive function before and after ICU admission.ResultsThirty-one patients requiring three days of sedation after microvascular reconstruction were initially enrolled in the study. Sedation in the ICU was maintained with propofol and dexmedetomidine combined with fentanyl. Cognitive function was assessed using a battery of 6 neuropsychological tests two days before surgery and three weeks after surgery. Finally, a total of 17 patients were included in the analysis. Cognitive impairment (defined as a decline of >20% from the pre-admission cognitive evaluation scores in at least two of 6 tests) was observed in 5 of the 17 patients (29%). However, there were no significant differences between the pre- and post-admission cognitive evaluations in 6 tests.ConclusionsMiddle-term cognitive function can be impaired in some patients subjected to deep sedation during several days following maxillary-mandibular oral surgery with microvascular reconstruction.Copyright © 2018 Elsevier España, S.L.U. y SEMICYUC. All rights reserved.

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